24" × 24"
Aluminum, rhino 3D, python
Aluminum surface of amino acid charge force
Proteasomes perform proteolytic degradation processes in the cell. Through a robust mechanism, the 20S core structure of these proteins disassemble unneeded or dysfunctional cellular units. Studying these interactions and functions of proteins in the cell requires extensive use of gel electrophoresis. Modern two dimensional gels separate proteins based on their isoelectric point (pl) and mass, while robotic techniques are commonly used for the isolation of results. I wanted to explore the biological incorporation of industrial robotics and the ubiquitin pathway rigidity of which proteasomes are a vital component.
An algorithm I developed reads the Protein Data Bank (PDB) file 1FNT. With an atomic resolution of 3.2 angstroms, I perform protein and amino acid calculations based of the crystal structure. The values of isoelectric forces, and molecular weights are used to determine geometries. Total protein calculations are initially performed to inform the program of relative values. Each amino acid is read sequently to determine X & Y position while downwards projections on the Z axis are a result of amino acid masses.